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Progestin challenge : ウィキペディア英語版 | Progestin challenge Progestin challenge, or progesterone withdrawal test is a test used in the field of obstetrics and gynecology in order to evaluate a patient who is experiencing amenorrhea. Due to readily available assays to measure serum estradiol levels, this test is now rarely used.〔(【引用サイトリンク】title=eMedicine - Amenorrhea, Secondary: Differential Diagnoses & Workup )〕 The test is performed by administering progesterone orally in the form of medroxyprogesterone acetate (Provera), or intramuscularly. If the patient has sufficient serum estradiol (greater than 50 pg/mL) then withdrawal bleeding should occur 2-7 days after the progestin is finished, indicating that the patient's amenorrhea is due to anovulation. However, if no bleeding occurs after progesterone withdrawal, then the patient's amenorrhea is likely to be due to either a) low serum estradiol, b) hypothalamic-pituitary axis dysfunction, c) a nonreactive endometrium or d) a problem with the uterine outflow tract, such as cervical stenosis or uterine synechiae (Asherman's syndrome). In order to distinguish between hypoestrogenism or a uterine outflow tract problem/nonreactive endometrium, estrogen may be administered followed by a course of progestin in order to induce withdrawal bleeding. If the patient experiences withdrawal bleeding with the combined estrogen/progestin therapy, then the amenorrhea is likely due to low estrogen.〔(【引用サイトリンク】title=Progesterone Withdrawal Test )〕 ==See also==
* Progestin * Progestogen * Progesterone
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Progestin challenge」の詳細全文を読む
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